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Distribution Diazepam and its metabolites are highly bound to plasma proteins (diazepam ninety eight%). Diazepam and its metabolites cross the blood-brain and placental obstacles and are present in breast milk in concentrations about a single tenth of Those people in maternal plasma (times 3 to 9 write-up-partum).
Diazepam je detektovan u majčinom mleku. Ukoliko je moguće, primenu diazepama tokom perioda dojenja treba izbegavati.
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This drug can decelerate your brain’s action and interfere together with your judgment, thinking, and motor capabilities. You should not drink alcohol or use other drugs that might also slow down your Mind’s exercise Whilst you’re using diazepam.
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The background threat of significant start defects and miscarriage for the indicated populace is unknown. All pregnancies have a background possibility of start defect, decline, or other adverse results.
For people with acute narrow-angle glaucoma: Talk with your medical doctor In case you have glaucoma. Diazepam may very well be Employed in individuals with open up-angle glaucoma, nonetheless it should not be Employed in those with acute slender-angle glaucoma.
Suicidal feelings or check here steps might be due to matters apart from medicines. Should you have suicidal feelings or actions, your healthcare company could check for other brings about.
Diazepam is obtainable since the brand name-name drug Valium. It’s also out there as a generic drug. Generic medication typically cost significantly less. In some cases, they will not be offered in every strength or type as the manufacturer-identify version.
For people with myasthenia gravis: If you have myasthenia gravis, you should not consider diazepam. Myasthenia gravis is read more really a sickness that causes extreme muscle weak point and tiredness.
Zavisnost: Hronična upotreba (čak i terapijskih doza) može dovesti do razvoja fizičke i psihičke zavisnosti: prekid terapije može dovesti do pojave rebound fenomena ili fenomena obustave (videti odeljak four.four). Prijavljena je i zloupotreba benzodiazepina.
Kod pacijenata sa oslabljenom funkcijom bubrega treba primenjivati opšte mere opreza. Kod pacijenata sa insuficijencijom bubrega poluvreme eliminacije diazepama nije klinički značajno promenjeno, pa obično nije neophodno prilagođavanje doze kod ovih pacijenata.
Taking particular antidepressants with diazepam can raise your hazard of drowsiness or sleepiness. It may also result in your respiration to slow down or end. These prescription drugs incorporate: